Muscarinic acetylcholine receptor M1

CHRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CXV
Identifiers
Aliases	CHRM1, HM1, M1, M1R, cholinergic receptor muscarinic 1
External IDs	OMIM: 118510; MGI: 88396; HomoloGene: 20189; GeneCards: CHRM1; OMA:CHRM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,921,807 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,660,951 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; middle temporal gyrus; ; Brodmann area 9; ; right frontal lobe; ; superior frontal gyrus; ; nucleus accumbens; ; postcentral gyrus; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; hippocampus proper; ; olfactory tubercle; ; nucleus accumbens; ; primary motor cortex; ; piriform cortex; ; prefrontal cortex; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylinositol phospholipase C activity; G protein-coupled acetylcholine receptor activity; neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	axon terminus; integral component of membrane; postsynaptic membrane; membrane; postsynaptic density; plasma membrane; integral component of plasma membrane; cell junction; dendrite; asymmetric synapse; synapse; Schaffer collateral - CA1 synapse; glutamatergic synapse; cholinergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of postsynaptic density membrane;
Biological process	positive regulation of intracellular protein transport; G protein-coupled receptor signaling pathway; cognition; regulation of locomotion; synaptic transmission, cholinergic; saliva secretion; nervous system development; neuromuscular synaptic transmission; protein kinase C-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; positive regulation of ion transport; positive regulation of cell population proliferation; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; cell population proliferation; regulation of vascular associated smooth muscle contraction; signal transduction; G protein-coupled acetylcholine receptor signaling pathway; regulation of postsynaptic membrane potential; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway; regulation of glial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1128
	12669
	ENSG00000168539
	ENSMUSG00000032773
	P11229
	P12657
	NM_000738
	NM_001112697; NM_007698
	NP_000729
	NP_001106167; NP_031724
	Wikidata
View/Edit Human	View/Edit Mouse

The muscarinic acetylcholine receptor M₁, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene. It is localized to 11q13.

This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve, is common in exocrine glands and in the CNS.

It is predominantly found bound to G proteins of class G_q that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, G_i (causing a downstream decrease in cAMP) and G_s (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.