MTA3

MTA3
Identifiers
Aliases	MTA3, metastasis associated 1 family member 3
External IDs	OMIM: 609050; MGI: 2151172; HomoloGene: 14282; GeneCards: MTA3; OMA:MTA3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	42,756,947 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	84,128,945 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; gonad; ; epithelium of colon; ; oocyte; ; left ovary; ; right ovary; ; ventricular zone; ; secondary oocyte;
	Top expressed in
	zygote; ; secondary oocyte; ; morula; ; primary oocyte; ; blastocyst; ; lip; ; genital tubercle; ; tail of embryo; ; blood; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; zinc ion binding; chromatin binding; protein binding; metal ion binding; histone deacetylase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein-containing complex binding; transcription coactivator activity; transcription corepressor activity; histone deacetylase binding;
Cellular component	intracellular membrane-bounded organelle; nucleus; nucleoplasm; cytoplasm; NuRD complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; histone deacetylation; positive regulation of cell population proliferation; positive regulation of G2/M transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	57504
	116871
	ENSG00000057935
	ENSMUSG00000055817
	Q9BTC8
	Q924K8
NM_001282755; NM_001282756; NM_020744; NM_001330442; NM_001330443;
	NM_001330444
NM_001171052; NM_001171053; NM_001171054; NM_054082; NM_001379388;
	NM_001379389; NM_001379390; NM_001379391; NM_001379392
NP_001269684; NP_001269685; NP_001317371; NP_001317372; NP_001317373;
	NP_065795
NP_001164523; NP_001164524; NP_001164525; NP_473423; NP_001366317;
	NP_001366318; NP_001366319; NP_001366320; NP_001366321
	Wikidata
View/Edit Human	View/Edit Mouse

Metastasis-associated protein MTA3 is a protein that in humans is encoded by the MTA3 gene. MTA3 protein localizes in the nucleus as well as in other cellular compartments MTA3 is a component of the nucleosome remodeling and deacetylate (NuRD) complex and participates in gene expression. The expression pattern of MTA3 is opposite to that of MTA1 and MTA2 during mammary gland tumorigenesis. However, MTA3 is also overexpressed in a variety of human cancers.