NOS1AP

NOS1AP
Identifiers
Aliases	NOS1AP, 6330408P19Rik, CAPON, nitric oxide synthase 1 adaptor protein, NPHS22
External IDs	OMIM: 605551; HomoloGene: 136252; GeneCards: NOS1AP; OMA:NOS1AP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,370,475 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; cerebellar vermis; ; frontal pole; ; orbitofrontal cortex; ; prefrontal cortex; ; paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; superior frontal gyrus; ; Brodmann area 46; ; parietal lobe;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nitric-oxide synthase binding;
Cellular component	L-type voltage-gated calcium channel complex; cytosol; nuclear membrane; inward rectifier potassium channel complex; perinuclear region of cytoplasm; sarcolemma; nucleus; mitochondrion; caveola; Z discdkac; T-tubule; sarcoplasmic reticulum membrane; glutamatergic synapse;
Biological process	positive regulation of peptidyl-cysteine S-nitrosylation; regulation of cardiac muscle cell action potential; positive regulation of nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity; positive regulation of delayed rectifier potassium channel activity; positive regulation of gene expression; positive regulation of nitric oxide mediated signal transduction; positive regulation of nitric-oxide synthase activity; regulation of high voltage-gated calcium channel activity; positive regulation of potassium ion transmembrane transport; regulation of heart rate by chemical signal; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; regulation of nitric oxide biosynthetic process; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; regulation of ventricular cardiac muscle cell membrane repolarization; postsynaptic actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	9722
	n/a
	ENSG00000198929
	n/a
	O75052
	n/a
	NM_014697; NM_001126060; NM_001164757
	n/a
	NP_001119532; NP_001158229; NP_055512
	n/a
	Wikidata
View/Edit Human

Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. NOS1AP polymorphisms has been associated with the QT interval length.