Neurotensin receptor 1

NTSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LYW
Identifiers
Aliases	NTSR1, NTR, Neurotensin receptor 1, neurotensin receptor 1 (high affinity), NTR1
External IDs	OMIM: 162651; MGI: 97386; HomoloGene: 68261; GeneCards: NTSR1; OMA:NTSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	62,762,771 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,186,773 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; granulocyte; ; substantia nigra; ; prefrontal cortex; ; monocyte; ; transverse colon; ; blood; ; ganglionic eminence; ; epithelium of colon; ; cingulate gyrus;
	Top expressed in
	barrel cortex; ; substantia nigra; ; ventral tegmental area; ; embryo; ; visual cortex; ; zygote; ; medullary collecting duct; ; dorsomedial hypothalamic nucleus; ; central gray substance of midbrain; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein homodimerization activity; protein N-terminus binding; signal transducer activity; protein binding; G protein-coupled neurotensin receptor activity; identical protein binding; protein heterodimerization activity;
Cellular component	cytoplasm; axon terminus; integral component of membrane; perikaryon; Golgi apparatus; membrane; plasma membrane; dendritic spine; integral component of plasma membrane; synapse; dendritic shaft; cell surface; axon; terminal bouton; soma; dendrite; symmetric synapse; endoplasmic reticulum; mitochondrion; neuron spine; membrane raft; cytoplasmic side of plasma membrane;
Biological process	positive regulation of cation channel activity; G protein-coupled receptor signaling pathway; regulation of sensory perception of pain; positive regulation of inositol phosphate biosynthetic process; positive regulation of inhibitory postsynaptic potential; adult locomotory behavior; regulation of respiratory gaseous exchange; negative regulation of apoptotic process; positive regulation of release of sequestered calcium ion into cytosol; D-aspartate import across plasma membrane; learning; inositol phosphate catabolic process; regulation of membrane depolarization; detection of temperature stimulus involved in sensory perception of pain; response to lipid; positive regulation of arachidonic acid secretion; positive regulation of glutamate secretion; positive regulation of apoptotic process; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of gamma-aminobutyric acid secretion; temperature homeostasis; neuropeptide signaling pathway; negative regulation of systemic arterial blood pressure; signal transduction; regulation of action potential; chemical synaptic transmission; L-glutamate import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	4923
	18216
	ENSG00000101188
	ENSMUSG00000027568
	P30989
	O88319
	NM_002531
	NM_018766
	NP_002522
	NP_061236
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. The neurotensin receptor is primarily responsible for mediating the effects of the neuropeptide neurotensin.