PSMB7

PSMB7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB7, proteasome subunit beta 7, Z, proteasome 20S subunit beta 7
External IDs	OMIM: 604030; MGI: 107637; HomoloGene: 2093; GeneCards: PSMB7; OMA:PSMB7 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	124,415,444 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	38,534,099 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; left testis; ; right testis; ; right adrenal gland; ; left adrenal gland; ; skin of leg; ; right adrenal cortex; ; left adrenal cortex; ; skin of abdomen;
	Top expressed in
	medial ganglionic eminence; ; somite; ; triceps brachii muscle; ; temporal muscle; ; mandibular prominence; ; digastric muscle; ; sternocleidomastoid muscle; ; maxillary prominence; ; right ventricle; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; extracellular region; cytoplasm; cytosol; secretory granule lumen; ficolin-1-rich granule lumen; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of protein targeting to mitochondrion; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5695
	19177
	ENSG00000136930
	ENSMUSG00000026750
	Q99436; Q5TBG5
	P70195
	NM_002799
	NM_011187
	NP_002790
	NP_035317
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the PSMB7 gene.

This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.