PSMB1

PSMB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB1, HC5, PMSB1, PSC5, proteasome subunit beta 1, proteasome 20S subunit beta 1
External IDs	OMIM: 602017; MGI: 104884; HomoloGene: 2087; GeneCards: PSMB1; OMA:PSMB1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	170,553,307 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,720,013 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; parietal pleura; ; visceral pleura; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; amniotic fluid; ; middle temporal gyrus; ; tibia; ; seminal vesicula; ; germinal epithelium;
	Top expressed in
	medial ganglionic eminence; ; facial motor nucleus; ; transitional epithelium of urinary bladder; ; efferent ductule; ; anterior horn of spinal cord; ; endocardial cushion; ; abdominal wall; ; right lung lobe; ; otic placode; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5689
	19170
	ENSG00000008018; ENSG00000281184
	ENSMUSG00000014769
	P20618
	O09061
	NM_002793
	NM_011185
	NP_002784
	NP_035315
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB1 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-1, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.