PSMB9

PSMB9
Identifiers
Aliases	PSMB9, LMP2, PSMB6i, RING12, beta1i, proteasome subunit beta 9, PRAAS3, proteasome 20S subunit beta 9
External IDs	OMIM: 177045; MGI: 1346526; HomoloGene: 2094; GeneCards: PSMB9; OMA:PSMB9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,859,851 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,406,738 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; lymph node; ; appendix; ; blood; ; spleen; ; duodenum; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; right lung;
	Top expressed in
	spleen; ; thymus; ; mesenteric lymph nodes; ; granulocyte; ; duodenum; ; jejunum; ; mucous cell of stomach; ; intestinal villus; ; blood; ; lactiferous gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	spermatoproteasome complex; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; cytoplasm; cytosol; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; regulation of cysteine-type endopeptidase activity; positive regulation of canonical Wnt signaling pathway; immune system process; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5698
	16912
ENSG00000240118; ENSG00000243067; ENSG00000240065; ENSG00000240508; ENSG00000242711;
	ENSG00000243594; ENSG00000243958; ENSG00000239836
	ENSMUSG00000096727
	P28065
	P28076
	NM_002800; NM_148954
	NM_013585
	NP_002791
	NP_038613
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene.

This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.