PSMB8

PSMB8
Identifiers
Aliases	PSMB8, ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10, proteasome subunit beta 8, PRAAS1, proteasome 20S subunit beta 8
External IDs	OMIM: 177046; MGI: 1346527; HomoloGene: 56499; GeneCards: PSMB8; OMA:PSMB8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,844,679 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; monocyte; ; lymph node; ; appendix; ; mucosa of transverse colon; ; duodenum; ; blood; ; rectum; ; olfactory zone of nasal mucosa;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; spermatoproteasome complex; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; proteasome core complex, beta-subunit complex;
Biological process	cell differentiation; antigen processing and presentation; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; immune system process; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; type I interferon signaling pathway; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; fat cell differentiation; negative regulation of canonical Wnt signaling pathway; regulation of endopeptidase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5696
	16913
ENSG00000230669; ENSG00000206298; ENSG00000230034; ENSG00000235715; ENSG00000231631;
	ENSG00000204264; ENSG00000226201; ENSG00000236443
	ENSMUSG00000024338
	P28062
	P28063
	NM_148919; NM_004159
	NM_010724
	NP_004150; NP_683720
	NP_034854
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the PSMB8 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.