PSMB5

PSMB5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB5, LMPX, MB1, proteasome subunit beta 5, X, proteasome 20S subunit beta 5
External IDs	OMIM: 600306; MGI: 1194513; HomoloGene: 55690; GeneCards: PSMB5; OMA:PSMB5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,035,230 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	54,855,479 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; islet of Langerhans; ; stromal cell of endometrium; ; muscle of thigh; ; right adrenal gland; ; ganglionic eminence; ; right adrenal cortex; ; left adrenal gland; ; deltoid muscle; ; left adrenal cortex;
	Top expressed in
	proximal tubule; ; right kidney; ; lens; ; neural tube; ; adrenal gland; ; quadriceps femoris muscle; ; lip; ; embryo; ; ventricular zone; ; Mesencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; centrosome; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; response to oxidative stress; proteolysis; MAPK cascade; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5693
	19173
	ENSG00000100804
	ENSMUSG00000022193
	P28074
	O55234
	NM_001130725; NM_001144932; NM_002797
	NM_011186
	NP_001124197; NP_001138404; NP_002788
	NP_035316
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-5 also known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.