SLPI

SLPI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z7F, 4DOQ
Identifiers
Aliases	SLPI, ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4, secretory leukocyte peptidase inhibitor
External IDs	OMIM: 107285; MGI: 109297; HomoloGene: 2305; GeneCards: SLPI; OMA:SLPI - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,254,564 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,231,015 bp
RNA expression pattern
	Top expressed in
	trachea; ; bronchus; ; epithelium of bronchus; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; nasal epithelium; ; minor salivary glands; ; palpebral conjunctiva; ; mucosa of paranasal sinus; ; parotid gland;
	Top expressed in
	esophagus; ; superior surface of tongue; ; granulocyte; ; submandibular gland; ; decidua; ; tibiofemoral joint; ; mesenteric lymph nodes; ; spleen; ; blood; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme binding; protein binding; serine-type endopeptidase inhibitor activity; DNA binding; mRNA binding; endopeptidase inhibitor activity;
Cellular component	extracellular matrix; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; specific granule lumen; collagen-containing extracellular matrix;
Biological process	antibacterial humoral response; response to lipopolysaccharide; negative regulation of viral genome replication; negative regulation of peptidase activity; innate immune response; negative regulation of protein binding; defense response to bacterium; immune response; negative regulation of endopeptidase activity; immune system process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	6590
	20568
	ENSG00000124107
	ENSMUSG00000017002
	P03973
	P97430
	NM_003064
	NM_011414
	NP_003055
	NP_035544
	Wikidata
View/Edit Human	View/Edit Mouse

Antileukoproteinase, also known as secretory leukocyte protease inhibitor (SLPI), is an enzyme that in humans is encoded by the SLPI gene. SLPI is a highly cationic single-chain protein with eight intramolecular disulfide bonds. It is found in large quantities in bronchial, cervical, and nasal mucosa, saliva, and seminal fluids. SLPI inhibits human leukocyte elastase, human cathepsin G, human trypsin, neutrophil elastase, and mast cell chymase. X-ray crystallography has shown that SLPI has two homologous domains of 53 and 54 amino acids, one of which exhibits anti-protease activity (C-terminal domain). The other domain (N-terminal domain) is not known to have any function.