SOCS6

SOCS6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VIF
Identifiers
Aliases	SOCS6, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6
External IDs	OMIM: 605118; MGI: 1924885; HomoloGene: 3120; GeneCards: SOCS6; OMA:SOCS6 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	70,330,199 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	88,945,605 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; jejunal mucosa; ; oral cavity; ; mucosa of colon; ; mucosa of sigmoid colon; ; Skeletal muscle tissue of biceps brachii; ; right ventricle; ; caput epididymis;
	Top expressed in
	otic vesicle; ; otic placode; ; zygote; ; saccule; ; secondary oocyte; ; pineal gland; ; yolk sac; ; intercostal muscle; ; soleus muscle; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; immunological synapse; cytosol; phosphatidylinositol 3-kinase complex;
Biological process	regulation of growth; defense response; proteasomal protein catabolic process; receptor signaling pathway via JAK-STAT; negative regulation of signal transduction; intracellular signal transduction; negative regulation of T cell activation; protein ubiquitination; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; post-translational protein modification; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9306
	54607
	ENSG00000170677
	ENSMUSG00000056153
	O14544
	Q9JLY0
	NM_004232; NM_016387
	NM_018821
	NP_004223
	NP_061291
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.