Secretin receptor family
| Secretin family of 7 transmembrane receptors | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | 7tm_2 | ||||||||
| Pfam | PF00002 | ||||||||
| InterPro | IPR000832 | ||||||||
| PROSITE | PDOC00559 | ||||||||
| TCDB | 9.A.14 | ||||||||
| OPM superfamily | 6 | ||||||||
| OPM protein | 4k5y | ||||||||
| CDD | cd13952 | ||||||||
| |||||||||
Secretin receptor family (class B GPCR subfamily) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family is different from adhesion G protein-coupled receptors.
The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have seven transmembrane helices, like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic 7TM signature.
The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in fungi, although due to their presumed non-hormonal function they are more commonly referred to as Adhesion G protein-coupled receptors, making the Adhesion subfamily the more basal group. Three distinct sub-families (B1-B3) are recognized.