MAP3K7IP2

TAB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DAE, 2WWZ, 2WX0, 2WX1
Identifiers
Aliases	TAB2, CHTD2, MAP3K7IP2, TAB-2, TGF-beta activated kinase 1/MAP3K7 binding protein 2, TGF-beta activated kinase 1 (MAP3K7) binding protein 2
External IDs	OMIM: 605101; MGI: 1915902; HomoloGene: 9019; GeneCards: TAB2; OMA:TAB2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,411,613 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,956,230 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; ventricular zone; ; epithelium of colon; ; gastrocnemius muscle; ; cartilage tissue; ; hair follicle; ; islet of Langerhans; ; monocyte; ; muscle layer of sigmoid colon; ; biceps brachii;
	Top expressed in
	plantaris muscle; ; extensor digitorum longus muscle; ; parotid gland; ; genital tubercle; ; left lung lobe; ; sciatic nerve; ; aortic valve; ; abdominal wall; ; mesenteric lymph nodes; ; migratory enteric neural crest cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; K63-linked polyubiquitin modification-dependent protein binding; protein binding;
Cellular component	endosome membrane; cytoplasm; membrane; plasma membrane; cytosol; nucleoplasm;
Biological process	JNK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase activity; Fc-epsilon receptor signaling pathway; heart development; nucleotide-binding oligomerization domain containing signaling pathway; MyD88-dependent toll-like receptor signaling pathway; stimulatory C-type lectin receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; negative regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB signaling; T cell receptor signaling pathway; interleukin-1-mediated signaling pathway; response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	23118
	68652
	ENSG00000055208
	ENSMUSG00000015755
	Q9NYJ8
	Q99K90
	NM_001292034; NM_001292035; NM_015093; NM_145342; NM_001369506
	NM_138667; NM_001359534
	NP_001278963; NP_001278964; NP_055908; NP_001356435
	NP_619608; NP_001346463
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Mutations in MAP3K7IP2 have been associated with human congenital heart defects.