U.S. Route 412 in Missouri
| US 412 highlighted in red | ||||
| Route information | ||||
| Maintained by MoDOT | ||||
| Length | 50.767 mi (81.702 km) | |||
| Major junctions | ||||
| West end | US 412 at Arkansas state line | |||
| I-55 / I-155 / US 61 in Hayti | ||||
| East end | I-155 / US 412 at Tennessee state line | |||
| Location | ||||
| Country | United States | |||
| State | Missouri | |||
| Counties | Dunklin, Pemiscot | |||
| Highway system | ||||
| 
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U.S. Route 412 (US 412) enters the state of Missouri from Arkansas near Cardwell. The highway leaves the state into Tennessee concurrent with I-155 near Caruthersville.