UBE2M

UBE2M
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TT5, 1Y8X, 2NVU, 3TDU, 3TDZ, 4GAO, 4P5O
Identifiers
Aliases	UBE2M, UBC-RS2, UBC12, hUbc12, ubiquitin conjugating enzyme E2 M
External IDs	OMIM: 603173; MGI: 108278; HomoloGene: 2952; GeneCards: UBE2M; OMA:UBE2M - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,558,954 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	12,772,202 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; anterior cingulate cortex; ; prefrontal cortex; ; left testis; ; apex of heart; ; anterior pituitary; ; right testis; ; muscle of thigh; ; Amygdala; ; right hemisphere of cerebellum;
	Top expressed in
	superior frontal gyrus; ; muscle of thigh; ; spermatocyte; ; lip; ; spermatid; ; ventricular zone; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; NEDD8 transferase activity; transferase activity;
Cellular component	cytoplasm; cytosol; nucleoplasm;
Biological process	protein neddylation; positive regulation of neuron apoptotic process; protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	9040
	22192
	ENSG00000130725
	ENSMUSG00000005575
	P61081
	P61082
	NM_003969
	NM_001168469; NM_001243968; NM_145578
	NP_003960; NP_003960.1
	NP_001161941; NP_001230897; NP_663553
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.