WAPAL

WAPL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4K6J, 5HDT
Identifiers
Aliases	WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
External IDs	OMIM: 610754; MGI: 2675859; HomoloGene: 41002; GeneCards: WAPL; OMA:WAPL - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	86,521,792 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	34,469,940 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; ventricular zone; ; amniotic fluid; ; gonad; ; testicle; ; skin of thigh; ; Achilles tendon; ; skin of hip; ; caput epididymis;
	Top expressed in
	zygote; ; secondary oocyte; ; tail of embryo; ; otolith organ; ; utricle; ; primary oocyte; ; hair follicle; ; Paneth cell; ; ureter; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; cohesin complex; chromosome; chromatin; synaptonemal complex; chromosome, centromeric region; nucleus; nucleoplasm;
Biological process	negative regulation of sister chromatid cohesion; negative regulation of chromatin binding; positive regulation of fibroblast proliferation; negative regulation of DNA replication; regulation of cohesin loading; cell division; regulation of chromosome segregation; cell cycle; viral process; protein localization to chromatin; response to toxic substance; mitotic sister chromatid cohesion; regulation of chromosome condensation; meiotic chromosome segregation; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	23063
	218914
	ENSG00000062650
	ENSMUSG00000041408
	Q7Z5K2
	Q65Z40
	NM_015045; NM_001318328
	NM_001004436; NM_001301330
	NP_001305257; NP_055860
	NP_001004436; NP_001288259
	Wikidata
View/Edit Human	View/Edit Mouse

Wings apart-like protein homolog (WAPL) is a protein that in humans is encoded by the WAPAL gene. WAPL is a key regulator of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. Cohesin has a ring-like arrangement and it is thought that it associates with the chromosome by entrapping it whether as a loop of DNA, a single strand or a pair of sister chromosomes. WAPL forms a complex with PDS5A or PDS5B and releases cohesin from DNA by opening the interface between SMC3 and RAD21.