WDHD1

WDHD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D7L
Identifiers
Aliases	WDHD1, AND-1, CHTF4, CTF4, AND1, WD repeat and HMG-box DNA binding protein 1, Ctf4
External IDs	OMIM: 608126; MGI: 2443514; HomoloGene: 56019; GeneCards: WDHD1; OMA:WDHD1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,027,105 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,514,314 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; testicle; ; ganglionic eminence; ; secondary oocyte; ; stromal cell of endometrium; ; epithelium of colon; ; mucosa of transverse colon; ; bone marrow cells; ; Achilles tendon;
	Top expressed in
	otic placode; ; otic vesicle; ; primitive streak; ; saccule; ; tail of embryo; ; epiblast; ; genital tubercle; ; ventricular zone; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA binding; chromatin binding; RNA binding; RNA polymerase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleoplasm; chromosome, centromeric region; replication fork protection complex; nuclear replication fork;
Biological process	RNA processing; regulation of chromosome organization; regulation of transcription by RNA polymerase II; mitotic cell cycle; DNA-dependent DNA replication; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	11169
	218973
	ENSG00000198554
	ENSMUSG00000037572
	O75717
	P59328
	NM_001008396; NM_007086
	NM_172598; NM_001360532
	NP_001008397; NP_009017
	NP_766186; NP_001347461
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene.

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].