ZBTB32

ZBTB32
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3M5B
Identifiers
Aliases	ZBTB32, FAXF, FAZF, Rog, TZFP, ZNF538, zinc finger and BTB domain containing 32
External IDs	OMIM: 605859; MGI: 1891838; HomoloGene: 8661; GeneCards: ZBTB32; OMA:ZBTB32 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,717,038 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,298,334 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; gonad; ; spleen; ; lymph node; ; right uterine tube; ; sural nerve; ; appendix; ; granulocyte;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; zygote; ; embryo; ; embryo; ; secondary oocyte; ; primary oocyte; ; blastocyst; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA binding; zinc ion binding; protein binding; transcription corepressor activity; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	27033
	58206
	ENSG00000011590
	ENSMUSG00000006310
	Q9Y2Y4
	Q9JKD9
	NM_014383; NM_001316902; NM_001316903
	NM_021397
	NP_001303831; NP_001303832; NP_055198
	NP_067372
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein (487 aa) is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.

The protein recruits histone modification enzymes to chromatin to affect gene activation. ZBTB32 recruits corepressors, such as N-CoR and HDACs to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with Blimp-1, to suppress the transcription of genes .

It contains a N-terminal BTB/POZ domain (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal zinc fingers, Znf_C2H2_sf. (IPR036236), Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative UBZ4 domain.