ZFPM2

ZFPM2
Identifiers
Aliases	ZFPM2, DIH3, FOG2, ZC2HC11B, ZNF89B, hFOG-2, SRXY9, zinc finger protein, FOG family member 2
External IDs	OMIM: 603693; MGI: 1334444; HomoloGene: 8008; GeneCards: ZFPM2; OMA:ZFPM2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	105,804,539 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	40,967,988 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; germinal epithelium; ; cartilage tissue; ; vastus lateralis muscle; ; glutes; ; cardiac muscle tissue of right atrium; ; triceps brachii muscle; ; Pons; ; parietal pleura; ; myocardium of left ventricle;
	Top expressed in
	atrioventricular valve; ; efferent ductule; ; endocardial cushion; ; lobe of cerebellum; ; cerebellar vermis; ; vas deferens; ; Gonadal ridge; ; lumbar subsegment of spinal cord; ; umbilical cord; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; transcription corepressor activity; zinc ion binding; transcription factor binding; metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; embryonic organ development; lung development; cardiac muscle tissue development; ventricular septum morphogenesis; right ventricular cardiac muscle tissue morphogenesis; blood coagulation; in utero embryonic development; negative regulation of transcription by RNA polymerase II; negative regulation of cell death; transcription, DNA-templated; outflow tract septum morphogenesis; vasculogenesis; positive regulation of transcription, DNA-templated; heart development; negative regulation of female gonad development; gonadal mesoderm development; negative regulation of transcription, DNA-templated; positive regulation of male gonad development; positive regulation of transcription by RNA polymerase II; positive regulation of cardiac muscle cell proliferation; cell differentiation; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	23414
	22762
	ENSG00000169946
	ENSMUSG00000022306
	Q8WW38
	Q8CCH7
	NM_012082; NM_001362836; NM_001362837
	NM_011766; NM_001356998
	NP_036214; NP_001349765; NP_001349766
	NP_035896; NP_001343927
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein that in humans is encoded by the ZFPM2 and in mice by the Zfpm2 gene.

The zinc finger-containing protein encoded by this gene is a widely expressed member of the FOG family of regulators of transcription factors. The family consists of the ZFPM1 and ZFPM2 genes in humans and Zfpm1 and Zfpm2 genes in mice. Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors. That is, the ZFPM2 protein appears able to interact directly with and thereby either enhance or repress the ability of GATA transcription factors to stimulate the expression of their target genes; the direction of ZFPM2's actions depends on the contexts of the promoter sections of the various GATA target genes.

The ZFPM2 protein interacts primarily with the GATA4 but also with GATA2, GATA5, and GATA6 transcription factors. ZFPM2 protein's interaction with GATA4 is notable for controlling the embryonic development of various tissues, particularly the heart, diaphragm, and gonads. Correspondingly, ZFPM2 mutations are responsible for certain forms of congenital heart defects, congenital diaphragmatic hernias, and ambiguous genitalia in mice as well as humans.