2022 United States Senate election in Missouri|
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  Congressional district resultsSchmitt:      40–50%      50–60%      60–70%      70–80%      80–90%Busch Valentine:       50–60%      60–70%      70–80%      80–90%
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The 2022 United States Senate election in Missouri was held on November 8, 2022, concurrently with elections for all other Class 3 U.S. senators and elections for the U.S. House of Representatives, to select a member of the United States Senate to represent the state of Missouri. Incumbent senator Roy Blunt, a Republican, did not seek a third term in office. Republican Missouri Attorney General Eric Schmitt won the open seat, defeating Democrat Trudy Busch Valentine.