Aquaporin-3

AQP3
Identifiers
Aliases	AQP3, AQP-3, GIL, aquaporin 3 (Gill blood group)
External IDs	OMIM: 600170; MGI: 1333777; HomoloGene: 21025; GeneCards: AQP3; OMA:AQP3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,447,596 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,098,183 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; gingival epithelium; ; mucosa of pharynx; ; epithelium of nasopharynx; ; parotid gland; ; human penis; ; palpebral conjunctiva; ; vulva; ; oral cavity; ; nipple;
	Top expressed in
	lip; ; olfactory epithelium; ; transitional epithelium of urinary bladder; ; yolk sac; ; esophagus; ; right kidney; ; mucous cell of stomach; ; skin of external ear; ; conjunctival fornix; ; cornea;
	More reference expression data
	n/a
Gene ontology
Molecular function	water channel activity; glycerol channel activity; transporter activity; channel activity; urea transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; membrane; cell-cell junction; plasma membrane; basolateral plasma membrane; nucleus;
Biological process	positive regulation of immune system process; excretion; response to vitamin D; response to retinoic acid; water transport; urea transport; odontogenesis; response to calcium ion; renal water homeostasis; regulation of keratinocyte differentiation; renal water absorption; glycerol transport; cellular response to oxygen-glucose deprivation; cellular response to hypoxia; transmembrane transport; urea transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	360
	11828
	ENSG00000165272
	ENSMUSG00000028435
	Q92482
	Q8R2N1
	NM_004925; NM_001318144
	NM_016689
	NP_001305073; NP_004916
	NP_057898
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers. In the kidney, aquaporin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. This protein is also a determinant for the GIL blood group system.

Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).