CEBPG

CEBPG
Identifiers
Aliases	CEBPG, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
External IDs	OMIM: 138972; MGI: 104982; HomoloGene: 1368; GeneCards: CEBPG; OMA:CEBPG - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	33,382,686 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	34,755,998 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; mucosa of colon; ; mucosa of sigmoid colon; ; muscle of thigh; ; middle temporal gyrus; ; mucosa of transverse colon; ; body of tongue; ; gingival epithelium; ; jejunum; ; jejunal mucosa;
	Top expressed in
	olfactory epithelium; ; condyle; ; parotid gland; ; zygote; ; conjunctival fornix; ; lacrimal gland; ; secondary oocyte; ; seminal vesicula; ; fossa; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; sequence-specific DNA binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of DNA repair; positive regulation of DNA-binding transcription factor activity; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; enucleate erythrocyte differentiation; immune response; mRNA metabolic process; B cell differentiation; positive regulation of DNA binding; positive regulation of transcription by RNA polymerase II; natural killer cell mediated cytotoxicity; transcription by RNA polymerase II; liver development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1054
	12611
	ENSG00000153879
	ENSMUSG00000056216
	P53567
	P53568
	NM_001806; NM_001252296
	NM_009884
	NP_001239225; NP_001797
	NP_034014
	Wikidata
View/Edit Human	View/Edit Mouse

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene. This gene has no introns.

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.

C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.

C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.