FANCD2

FANCD2
Identifiers
Aliases	FANCD2, FA-D2, FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia complementation group D2, FA complementation group D2
External IDs	OMIM: 613984; MGI: 2448480; HomoloGene: 13212; GeneCards: FANCD2; OMA:FANCD2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	10,101,932 bp
RNA expression pattern
	Top expressed in
	testicle; ; ventricular zone; ; secondary oocyte; ; right testis; ; left testis; ; ganglionic eminence; ; bone marrow cells; ; buccal mucosa cell; ; mucosa of transverse colon; ; gonad;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA polymerase binding;
Cellular component	nucleolus; nucleus; nucleoplasm; condensed chromosome; cytosol; nuclear body;
Biological process	cell cycle; gamete generation; homologous chromosome pairing at meiosis; response to gamma radiation; interstrand cross-link repair; cellular response to DNA damage stimulus; regulation of DNA-binding transcription factor activity; regulation of CD40 signaling pathway; regulation of regulatory T cell differentiation; brain morphogenesis; neuronal stem cell population maintenance; regulation of inflammatory response; cellular response to oxidative stress; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	2177
	211651
	ENSG00000144554
	n/a
	Q9BXW9
	Q80V62
NM_001018115; NM_033084; NM_001319984; NM_001374253; NM_001374254;
	NM_001374255
	NM_001033244; NM_001347350
NP_001018125; NP_001306913; NP_149075; NP_001361182; NP_001361183;
	NP_001361184
	NP_001028416; NP_001334279
	Wikidata
View/Edit Human	View/Edit Mouse

Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2 (this gene), FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCO, FANCP, FANCQ, FANCR, FANCS, FANCT, FANCU, FANCV, and probably FANCW. Fanconi anemia proteins, including FANCD2, are an emerging therapeutic target in cancer