NEDD4

NEDD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KPZ, 2KQ0, 2M3O, 2XBB, 2XBF, 3B7Y, 4BBN, 4BE8, 4N7F, 4N7H, 5C91, 5AHT, 5C7J
Identifiers
Aliases	NEDD4, NEDD4-1, RPF1, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, NEDD4 E3 ubiquitin protein ligase
External IDs	OMIM: 602278; MGI: 97297; HomoloGene: 136740; GeneCards: NEDD4; OMA:NEDD4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	55,993,660 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	72,749,852 bp
RNA expression pattern
	Top expressed in
	testicle; ; epithelium of colon; ; Skeletal muscle tissue of rectus abdominis; ; Achilles tendon; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; glutes; ; gastrocnemius muscle;
	Top expressed in
	efferent ductule; ; tail of embryo; ; vestibular membrane of cochlear duct; ; hand; ; primitive streak; ; genital tubercle; ; mandibular prominence; ; medullary collecting duct; ; maxillary prominence; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; ubiquitin-protein transferase activity; sodium channel inhibitor activity; beta-2 adrenergic receptor binding; ubiquitin binding; protein binding; RNA polymerase binding; proline-rich region binding; phosphoserine residue binding; phosphothreonine residue binding; ionotropic glutamate receptor binding; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; ubiquitin ligase complex; plasma membrane; apicolateral plasma membrane; cell cortex; perinuclear region of cytoplasm; chromatin; extracellular exosome; dendritic spine; glutamatergic synapse; postsynaptic cytosol;
Biological process	protein targeting to lysosome; adaptive immune response; positive regulation of protein catabolic process; blood vessel morphogenesis; negative regulation of sodium ion transport; cellular response to UV; endocardial cushion development; negative regulation of vascular endothelial growth factor receptor signaling pathway; protein K63-linked ubiquitination; regulation of membrane potential; negative regulation of sodium ion transmembrane transporter activity; regulation of ion transmembrane transport; negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; outflow tract morphogenesis; receptor internalization; negative regulation of transcription by RNA polymerase II; protein monoubiquitination; receptor catabolic process; nervous system development; regulation of dendrite morphogenesis; response to calcium ion; positive regulation of nucleocytoplasmic transport; neuromuscular junction development; protein ubiquitination; regulation of potassium ion transmembrane transporter activity; lysosomal transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; positive regulation of phosphatidylinositol 3-kinase signaling; progesterone receptor signaling pathway; viral process; neuron projection development; regulation of synapse organization; T cell activation; regulation of macroautophagy; glucocorticoid receptor signaling pathway; protein polyubiquitination; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4734
	17999
	ENSG00000069869
	ENSMUSG00000032216
	P46934
	P46935
NM_001284338; NM_001284339; NM_001284340; NM_006154; NM_198400;
	NM_001329212
	NM_010890
NP_001271267; NP_001271268; NP_001271269; NP_001316141; NP_006145;
	NP_940682
	NP_035020; NP_001344927
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the NEDD4 gene.

NEDD4 is an E3 ubiquitin ligase enzyme, that targets proteins for ubiquitination. NEDD4 is, in eukaryotes, a highly conserved gene, and the founding member of the NEDD4 family of E3 HECT ubiquitin ligases, which in humans consists of 9 members:

NEDD4 (the core topic of this article)
NEDD4-2 (or NEDD4L)
ITCH
SMURF1
SMURF2
WWP1
WWP2
NEDL1 (HECW1)
NEDDL2 (HECW2)].

NEDD4 regulates a large number of membrane proteins, such as ion channels and membrane receptors, via ubiquitination and endocytosis; its eponymous protein is widely expressed, and a large number of proteins have been predicted or demonstrated to bind in vitro.

In vivo, it is involved in the regulation of a diverse range of processes, including

insulin-like growth factor signalling,
neuronal architecture, and
viral budding.

NEDD4 also is an essential protein in animals, both for development and for survival.