P21-activated kinases

p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

  • PAK1, regulating cell motility and morphology
  • PAK2, possibly playing a role in apoptosis
  • PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
  • PAK4, a mediator of filopodia formation
  • PAK5, a mediator of filopodia formation
  • PAK6, involved in cytoskeleton rearrangement
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