PSMC1

PSMC1
Identifiers
Aliases	PSMC1, P26S4, S4, p56, proteasome 26S subunit, ATPase 1, RPT2
External IDs	OMIM: 602706; MGI: 106054; HomoloGene: 2095; GeneCards: PSMC1; OMA:PSMC1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	90,275,429 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	100,089,664 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastrocnemius muscle; ; islet of Langerhans; ; muscle of thigh; ; skeletal muscle tissue; ; placenta; ; smooth muscle tissue; ; left testis; ; endometrium; ; right testis;
	Top expressed in
	yolk sac; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; lens; ; ventricular zone; ; Cerebellum; ; olfactory bulb; ; neural tube; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; ATP binding; hydrolase activity; TBP-class protein binding; RNA binding; proteasome-activating activity;
Cellular component	nuclear proteasome complex; proteasome regulatory particle, base subcomplex; proteasome regulatory particle; cytosolic proteasome complex; proteasome accessory complex; membrane; nucleoplasm; nucleus; proteasome complex; cytoplasm; cytosol;
Biological process	positive regulation of RNA polymerase II transcription preinitiation complex assembly; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; protein catabolic process; NIK/NF-kappaB signaling; ubiquitin-dependent ERAD pathway; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of neuron death; Wnt signaling pathway, planar cell polarity pathway; positive regulation of proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein folding; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5700
	19179
	ENSG00000100764
	ENSMUSG00000021178
	P62191
	P62192
	NM_002802; NM_001330212
	NM_008947
	NP_001317141; NP_002793
	NP_032973
	Wikidata
View/Edit Human	View/Edit Mouse

26S protease regulatory subunit 4, also known as 26S proteasome AAA-ATPase subunit Rpt2, is an enzyme that in humans is encoded by the PSMC1 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2 (this protein), Rpt3, Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.