PSMC4

PSMC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DVW
Identifiers
Aliases	PSMC4, MIP224, RPT3, S6, TBP-7, TBP7, proteasome 26S subunit, ATPase 4
External IDs	OMIM: 602707; MGI: 1346093; HomoloGene: 4744; GeneCards: PSMC4; OMA:PSMC4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,981,764 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,749,526 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; mucosa of transverse colon; ; stromal cell of endometrium; ; placenta; ; appendix; ; prefrontal cortex; ; muscle of thigh; ; islet of Langerhans; ; granulocyte; ; smooth muscle tissue;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; abdominal wall; ; Rostral migratory stream; ; condyle; ; medial ganglionic eminence; ; fossa; ; vas deferens; ; endocardial cushion; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; ATPase activity; hydrolase activity; TBP-class protein binding; ATP binding; protein binding; proteasome-activating activity;
Cellular component	proteasome regulatory particle, base subcomplex; inclusion body; cytosolic proteasome complex; membrane; nuclear proteasome complex; proteasome accessory complex; proteasome complex; nucleus; nucleoplasm; cytoplasm; cytosol; synapse;
Biological process	NIK/NF-kappaB signaling; proteolysis; MAPK cascade; regulation of mRNA stability; protein polyubiquitination; Fc-epsilon receptor signaling pathway; regulation of cellular amino acid metabolic process; protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; tumor necrosis factor-mediated signaling pathway; blastocyst development; stimulatory C-type lectin receptor signaling pathway; ubiquitin-dependent ERAD pathway; anaphase-promoting complex-dependent catabolic process; negative regulation of canonical Wnt signaling pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; T cell receptor signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5704
	23996
	ENSG00000281221; ENSG00000013275
	ENSMUSG00000030603
	P43686
	P54775
	NM_153001; NM_006503
	NM_011874
	NP_006494; NP_694546
	NP_036004
	Wikidata
View/Edit Human	View/Edit Mouse

26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3, is an enzyme that in humans is encoded by the PSMC4 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3 (this protein), Rpt4, Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.