PSMC3

PSMC3
Identifiers
Aliases	PSMC3, TBP1, proteasome 26S subunit, ATPase 3, RPT5, DCIDP
External IDs	OMIM: 186852; MGI: 1098754; HomoloGene: 2097; GeneCards: PSMC3; OMA:PSMC3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,426,473 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,896,714 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; muscle of thigh; ; islet of Langerhans; ; ganglionic eminence; ; popliteal artery; ; tibial arteries; ; caudate nucleus; ; Achilles tendon; ; right auricle of heart;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; endocardial cushion; ; mandibular prominence; ; yolk sac; ; maxillary prominence; ; lens; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; hydrolase activity; TBP-class protein binding; ATP binding; protein binding; identical protein binding; proteasome-activating activity;
Cellular component	nucleoplasm; cytoplasm; proteasome regulatory particle, base subcomplex; cytosol; cytosolic proteasome complex; membrane; P-body; proteasome accessory complex; nuclear proteasome complex; proteasome complex; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; nucleus;
Biological process	NIK/NF-kappaB signaling; MAPK cascade; regulation of mRNA stability; protein polyubiquitination; Fc-epsilon receptor signaling pathway; regulation of cellular amino acid metabolic process; protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; tumor necrosis factor-mediated signaling pathway; blastocyst development; stimulatory C-type lectin receptor signaling pathway; ubiquitin-dependent ERAD pathway; anaphase-promoting complex-dependent catabolic process; negative regulation of canonical Wnt signaling pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; T cell receptor signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; modulation by host of viral transcription; positive regulation of transcription by RNA polymerase II; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5702
	19182
	ENSG00000165916
	ENSMUSG00000002102
	P17980
	O88685
	NM_002804
	NM_008948
	NP_002795
	NP_032974
	Wikidata
View/Edit Human	View/Edit Mouse

26S protease regulatory subunit 6A, also known as 26S proteasome AAA-ATPase subunit Rpt5, is an enzyme that in humans is encoded by the PSMC3 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4, Rpt5 (this protein), and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.