PSMC5

PSMC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KRK, 3KW6
Identifiers
Aliases	PSMC5, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG, proteasome 26S subunit, ATPase 5, RPT6
External IDs	OMIM: 601681; MGI: 105047; HomoloGene: 2098; GeneCards: PSMC5; OMA:PSMC5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,832,026 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,153,946 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right testis; ; gastrocnemius muscle; ; left testis; ; anterior pituitary; ; gastric mucosa; ; islet of Langerhans;
	Top expressed in
	otic placode; ; saccule; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; dorsal tegmental nucleus; ; pontine nuclei; ; tail of embryo; ; somite; ; otic vesicle; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; thyrotropin-releasing hormone receptor binding; protein binding; ATP binding; signaling receptor binding; hydrolase activity; ATPase activity; TBP-class protein binding; transcription factor binding; proteasome-activating activity;
Cellular component	cytosol; proteasome regulatory particle, base subcomplex; blood microparticle; membrane; proteasome regulatory particle; nucleoplasm; inclusion body; extracellular exosome; cytoplasmic vesicle; proteasome complex; cytosolic proteasome complex; cytoplasm; proteasome accessory complex; nucleus; nuclear proteasome complex; postsynapse;
Biological process	positive regulation of RNA polymerase II transcription preinitiation complex assembly; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; positive regulation of inclusion body assembly; MAPK cascade; positive regulation of transcription, DNA-templated; Fc-epsilon receptor signaling pathway; protein catabolic process; NIK/NF-kappaB signaling; ubiquitin-dependent ERAD pathway; negative regulation of programmed cell death; anaphase-promoting complex-dependent catabolic process; negative regulation of transcription, DNA-templated; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; positive regulation of proteasomal protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; modulation of chemical synaptic transmission; regulation of transcription by RNA polymerase II; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5705
	19184
	ENSG00000087191
	ENSMUSG00000020708
	P62195
	P62196
	NM_001199163; NM_002805
	NM_008950
	NP_001186092; NP_002796
	NP_032976
	Wikidata
View/Edit Human	View/Edit Mouse

26S protease regulatory subunit 8, also known as 26S proteasome AAA-ATPase subunit Rpt6, is an enzyme that in humans is encoded by the PSMC5 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4, Rpt5, and Rpt6 (this protein)) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.