PSMC6

PSMC6
Identifiers
Aliases	PSMC6, CADP44, HEL-S-73, P44, SUG2, p42, proteasome 26S subunit, ATPase 6, RPT5
External IDs	OMIM: 602708; MGI: 1914339; HomoloGene: 100630; GeneCards: PSMC6; OMA:PSMC6 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	52,728,590 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	45,587,162 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; amniotic fluid; ; tibia; ; germinal epithelium; ; visceral pleura; ; parietal pleura; ; mucosa of paranasal sinus; ; oral cavity;
	Top expressed in
	atrioventricular valve; ; mandibular prominence; ; maxillary prominence; ; abdominal wall; ; otic placode; ; olfactory epithelium; ; extensor digitorum longus muscle; ; plantaris muscle; ; medial ganglionic eminence; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein-macromolecule adaptor activity; ATPase activity; protein binding; TBP-class protein binding; ATP binding; hydrolase activity; identical protein binding; proteasome-activating activity;
Cellular component	cytoplasm; nuclear proteasome complex; cytosol; proteasome regulatory particle, base subcomplex; membrane; proteasome accessory complex; nucleoplasm; cytosolic proteasome complex; proteasome complex; extracellular exosome; nucleus;
Biological process	positive regulation of RNA polymerase II transcription preinitiation complex assembly; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; protein catabolic process; NIK/NF-kappaB signaling; ubiquitin-dependent ERAD pathway; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5706
	67089
	ENSG00000100519
	ENSMUSG00000021832
	P62333
	P62334
	NM_002806; NM_001366414
	NM_025959
	NP_002797; NP_001353343
	NP_080235
	Wikidata
View/Edit Human	View/Edit Mouse

26S protease regulatory subunit S10B, also known as 26S proteasome AAA-ATPase subunit Rpt4, is an enzyme that in humans is encoded by the PSMC6 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4 (this protein), Rpt5, and Rpt6) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex.