PSMD14

PSMD14
Identifiers
Aliases	PSMD14, PAD1, POH1, RPN11, proteasome 26S subunit, non-ATPase 14
External IDs	OMIM: 607173; MGI: 1913284; HomoloGene: 4240; GeneCards: PSMD14; OMA:PSMD14 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	161,411,717 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	61,630,720 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; deltoid muscle; ; glutes; ; tibialis anterior muscle; ; triceps brachii muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Brodmann area 23; ; gingival epithelium;
	Top expressed in
	endothelial cell of lymphatic vessel; ; primitive streak; ; medial ganglionic eminence; ; facial motor nucleus; ; hair follicle; ; renal corpuscle; ; otic placode; ; Paneth cell; ; condyle; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; endopeptidase activator activity; proteasome binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; thiol-dependent deubiquitinase; Lys63-specific deubiquitinase activity;
Cellular component	cytosol; proteasome accessory complex; nucleoplasm; cytosolic proteasome complex; proteasome regulatory particle, lid subcomplex; proteasome complex; extracellular exosome; nucleus; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	regulation of proteasomal protein catabolic process; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ubiquitin-dependent protein catabolic process; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; cellular response to DNA damage stimulus; Fc-epsilon receptor signaling pathway; protein K63-linked deubiquitination; NIK/NF-kappaB signaling; double-strand break repair via homologous recombination; anaphase-promoting complex-dependent catabolic process; response to ethanol; double-strand break repair via nonhomologous end joining; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; DNA repair; positive regulation of endopeptidase activity; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; neutrophil degranulation; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	10213
	59029
	ENSG00000115233
	ENSMUSG00000026914
	O00487
	O35593
	NM_005805
	NM_021526
	NP_005796
	NP_067501
	Wikidata
View/Edit Human	View/Edit Mouse

26S proteasome non-ATPase regulatory subunit 14, also known as 26S proteasome non-ATPase subunit Rpn11, is an enzyme that in humans is encoded by the PSMD14 gene. This protein is one of the 19 essential subunits of the complete assembled 19S proteasome complex. Nine subunits Rpn3, Rpn5, Rpn6, Rpn7, Rpn8, Rpn9, Rpn11, SEM1 (yeast analogue for human protein DSS1), and Rpn12 form the lid sub complex of the 19S regulatory particle of the proteasome complex.